Key result
Interferon therapy does not alter circadian blood pressure or heart rate variability in normotensive subjects.
Why the study?
Does interferon therapy alter circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis?
Observational
Does interferon therapy alter circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis?
Interferon therapy does not significantly alter autonomic tone or circadian blood pressure rhythms in normotensive patients with chronic active hepatitis.
Interferon appears not to disrupt circadian BP or HRV rhythms in normotensive hepatitis patients; leaves open effects in hypertensive or broader populations.
We have determined the effects of interferon therapy on circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis. Body temperature and pulse rate increased for the initial few days of interferon therapy without significant change in casual or ambulatory blood pressure. Interferon therapy failed to elicit any significant changes in the power spectrum of R-R intervals. In addition, urinary excretion of norepinephrine did not differ between before and during the therapy. These results suggest that interferon therapy caused transient increases in body temperature and pulse rate, but that it did not change either sympathetic or parasympathetic outflow, or the circadian rhythm of blood pressure and heart rate variability, in normotensive subjects.
No takes yet. Share an insight, caveat, or question.
Masayo Fukuhara (1999) conducted an observational in Chronic active hepatitis. Interferon therapy vs. Before therapy (baseline) was evaluated on Circadian changes in blood pressure and heart rate variability. Interferon therapy caused transient increases in body temperature and pulse rate but did not change the circadian rhythm of blood pressure or heart rate variability in normotensive subjects.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: