Why the study?
Does interferon alfa-2b therapy increase psychiatric symptoms in patients with chronic hepatitis C?
Population
104 patients with chronic hepatitis C
Comparison
Interferon alfa-2b for up to 12 months vs Untreated reference group (no treatment)
Design
Cohort
Follow-up
up to 12 months
Authors
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May support psychiatric monitoring during interferon alfa; leaves open causality and need for randomized confirmation.
Does interferon alfa-2b therapy increase psychiatric symptoms in patients with chronic hepatitis C?
Interferon alfa-2b therapy in patients with chronic hepatitis C is associated with a significant increase in psychiatric symptoms, including depression and anger/hostility, necessitating close monitoring.
Kraus et al. (2003) studied this question.
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