Why the study?
What are the biopsychosocial predictors of interferon-alpha-induced depression in patients with chronic hepatitis C infection?
Population
41 patients with chronic hepatitis C (HCV) infection
Design
Cohort
Follow-up
Up to 9 months of treatment and 3 months post-treatment
Authors
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High IFN-α-related depression incidence supports routine monitoring in hepatitis C; leaves open validation of biopsychosocial predictors.
What are the biopsychosocial predictors of interferon-alpha-induced depression in patients with chronic hepatitis C infection?
Over half of patients with chronic hepatitis C treated with interferon-alpha develop depression, which is associated with both biological (tryptophan depletion) and psychosocial risk factors.
Baranyi et al. (2013) studied this question.
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