Key result
Pre-existing psychiatric disorders were associated with a significantly lower risk of long-term worsening of depressive symptoms 6 months after interferon-alpha treatment (OR 0.117; 95% CI 0.024-0.558).
Why the study?
Do pre-existing psychiatric risk factors influence long-term mental health changes after interferon-alpha treatment in hepatitis C patients?
Population
81 hepatitis C virus-infected patients
Design
Cohort
Follow-up
6 months after the end of antiviral treatment
Authors
Loading...
Should not yet alter pre-treatment psychiatric screening; leaves open need for prospective validation in hepatitis C cohorts.
Cohort (n=81)
Do pre-existing psychiatric risk factors influence long-term mental health changes after interferon-alpha treatment in hepatitis C patients?
Odds Ratio: 0.117 (95% CI 0.024–0.558)
Pre-existing psychiatric risk factors increase the chance for a long-term improvement and reduce the risk for a long-term worsening of mental health after antiviral treatment of chronic hepatitis C with IFN-alpha.
Schmidt et al. (2009) conducted a cohort in Chronic hepatitis C (n=81). Pre-existing psychiatric disorders vs. No pre-existing psychiatric disorders was evaluated on Long-term worsening of depressive symptoms (OR 0.117, 95% CI 0.024-0.558). Pre-existing psychiatric disorders were associated with a significantly lower risk of long-term worsening of depressive symptoms 6 months after interferon-alpha treatment (OR 0.117; 95% CI 0.024-0.558).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: