Key result
Interferon-alpha and ribavirin therapy in HIV/HCV co-infected patients was associated with a 40% incidence of depressive symptoms, which mostly improved with antidepressant treatment.
Why the study?
What is the incidence of depressive symptoms in HIV-infected patients with chronic hepatitis C treated with interferon-alpha?
Population
113 HIV-infected patients with chronic hepatitis C who began interferon-alpha and ribavirin therapy…
Design
Cohort
Authors
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Depressive symptoms warrant monitoring during interferon therapy in HIV/HCV co-infection; leaves open optimal prevention strategies in prospective trials.
Cohort (n=113)
What is the incidence of depressive symptoms in HIV-infected patients with chronic hepatitis C treated with interferon-alpha?
Interferon-alpha therapy in HIV/HCV co-infected patients is associated with a high incidence of depressive symptoms, which can be effectively managed with antidepressants like citalopram.
Laguno et al. (2004) conducted a cohort in HIV/HCV co-infection (n=113). Interferon-alpha and ribavirin therapy was evaluated on Development of symptoms of depression. Interferon-alpha and ribavirin therapy in HIV/HCV co-infected patients was associated with a 40% incidence of depressive symptoms, which mostly improved with antidepressant treatment.
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