Key result
Higher Lp(a) linked to more severe carotid atherosclerosis in young adults with ischemic stroke.
Why the study?
Elevated lipoprotein (a) is associated with carotid atherosclerosis in middle-aged and older patients with ischemic stroke, but this association had not been explored in young patients with stroke.
Is elevated Lipoprotein (a) associated with carotid atherosclerosis in young patients with ischemic stroke?
Comparison
Grades of carotid atherosclerosis (none vs plaque without stenosis vs stenosis >=50%) by lipoprotein (a) levels
Design
Retrospective analysis
Authors
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May inform Lp(a) testing in young stroke patients; leaves open whether lowering Lp(a) alters carotid progression or outcomes.
Observational (n=196)
No
Is elevated Lipoprotein (a) associated with carotid atherosclerosis in young patients with ischemic stroke?
p-value: p=<0.001
Elevated lipoprotein (a) is independently associated with the presence and severity of carotid atherosclerosis in young adults with ischemic stroke.
Nasr et al. (2011) conducted an observational in Acute ischemic stroke (n=196). Lipoprotein (a) plasma concentration was evaluated on Carotid atherosclerosis severity (no atherosclerosis, plaque without stenosis, or stenosis ≥50%) (p=<0.001). Lipoprotein (a) plasma concentration showed a strong, graded, and independent association with carotid atherosclerosis severity in young adults with ischemic stroke (P<0.001).
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