Key result
HCR yields similar 12-month quality of life improvements to CABG in multivessel CAD.
Why the study?
Does hybrid coronary revascularization improve health-related quality of life compared to conventional coronary artery bypass grafting in patients with multivessel coronary artery disease?
RCT (n=200)
Open-label
1:1 ratio
No
Does hybrid coronary revascularization improve health-related quality of life compared to conventional coronary artery bypass grafting in patients with multivessel coronary artery disease?
Absolute Event Rate: 13.5% vs 10.48%
p-value: p=0.76
Hybrid coronary revascularization provides similar improvements in health-related quality of life at 12 months compared to conventional CABG in patients with multivessel coronary artery disease.
Permits revascularization choice based on procedural risks or recovery rather than quality-of-life differences; extends randomized evidence for hybrid approaches.
BACKGROUND: Patients with stable coronary artery disease (CAD) have a worse quality of life (QoL) in comparison to patients without stable CAD. Standardized questionnaires are used in evaluation of QoL. Hybrid coronary revascularization (HCR) is a recently-introduced, minimally invasive option for patients requiring revascularization for coronary lesions. The aim of this study was to assess healthrelated quality of life (HRQoL) in patients with multivessel CAD (MVCAD), according to the mode of revascularization: coronary artery bypass grafting (CABG) or HCR, using the generic SF-36 v.2 questionnaire. METHODS: From November 2009 to July 2012, 200 patients from POLMIDES study with diagnosed MVCAD and were referred for conventional CABG were randomized to HCR (n = 98) or CABG (n =102) groups in 1:1 ratio. HRQoL were measured at two time points: hospital admission and 12-month follow up. The primary endpoint was the difference in HRQoL after the procedure. RESULTS: Both groups showed the same improvement of HRQoL: in HCR group: 13.5 (3.82-22.34) vs. CABG group: 10.48 (2.46-31.07); p = 0.76. CONCLUSIONS: HRQoL in patients after both modes of revascularization significantly improved after 12 months in all domains.
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Gierszewska et al. (2017) conducted an RCT in Multivessel coronary artery disease (n=200). Hybrid coronary revascularization vs. Coronary artery bypass grafting (CABG) was evaluated on Difference in health-related quality of life (HRQoL) after the procedure (p=0.76). Hybrid coronary revascularization and coronary artery bypass grafting resulted in similar improvements in health-related quality of life at 12 months (p = 0.76) in patients with multivessel coronary artery disease.
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