Key result
GDMT with anticoagulation normalizes LVEF to 57% and resolves LV thrombus.
Why the study?
Severe peripartum cardiomyopathy may be complicated by intracardiac thrombi and systemic embolisation due to left ventricular dysfunction and the hypercoagulable puerperium state.
Case Report (n=1)
No
Severe peripartum cardiomyopathy can present with extensive thromboembolic complications, but early recognition, guideline-directed heart failure therapy, and individualized anticoagulation can lead to complete ventricular recovery and thrombus resolution.
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Suggests potential for full recovery with medical therapy in severe peripartum cardiomyopathy with thrombi; leaves open need for prospective confirmation.
Achour et al. (2026) conducted a case report in Severe peripartum cardiomyopathy with multiple left ventricular thrombi and systemic embolic events (n=1). Guideline-directed heart failure therapy and therapeutic anticoagulation was evaluated on Left ventricular recovery and thrombus resolution. Guideline-directed heart failure therapy and therapeutic anticoagulation resulted in complete normalization of left ventricular ejection fraction to 57% and full thrombus resolution by eight months.
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