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June 28, 2011Acta Neurologica Scandinavica

Subclinical carotid atherosclerosis and cognitive function

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Key result

Subclinical carotid atherosclerosis is linked to cognitive decline and dementia through various proposed mechanisms.

Why the study?

Recent studies indicated that carotid atherosclerosis without clinical stroke may be an independent risk factor for cognitive decline and dementia, warranting a review of the association and potential underlying mechanisms.

Is subclinical carotid atherosclerosis an independent risk factor for cognitive decline and dementia?

Design

Brief review

Authors

KAKjell Arne ArntzenEMEllisiv B. Mathiesen

Discussion

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Overview

Subclinical carotid atherosclerosis may mark elevated cognitive risk; leaves open independent causality and screening utility pending prospective data.

Structured PICO

Is subclinical carotid atherosclerosis an independent risk factor for cognitive decline and dementia?

P
Population
Individuals with subclinical carotid atherosclerosis without clinical stroke
E
Exposure
Presence of subclinical carotid atherosclerosis (assessed via ultrasonography)
C
Comparator
Absence of subclinical carotid atherosclerosis
O
Outcome
Cognitive function, cognitive decline, and dementia

Subclinical carotid atherosclerosis, measurable by non-invasive ultrasonography, may serve as an independent risk factor for cognitive impairment and dementia even in the absence of clinical stroke.

Cite This Study

Arntzen et al. (2011) conducted a review in Subclinical carotid atherosclerosis and cognitive impairment. Subclinical carotid atherosclerosis was evaluated on Cognitive function and dementia. This review discusses studies investigating the relationship between subclinical carotid atherosclerosis and cognitive decline or dementia, along with possible underlying mechanisms.

synapsesocial.com/papers/6aa7b0383da0e7dbac712efdhttps://doi.org/10.1111/j.1600-0404.2011.01538.x
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Also Consider

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  1. 1Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment2009 · 313 citations
  2. 2Carotid‐ intima media thickness is independently associated with cognitive decline. The INVADE study2009 · 87 citations
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  5. 5Statins for the prevention of dementia2009 · 193 citations