Key result
Adding MAFLD to CKM staging improves mortality risk stratification, showing ~3.8-fold higher risk in advanced stages.
Why the study?
Does integrating MAFLD into the CKM framework improve mortality risk discrimination compared with the original CKM framework in adults?
Population
10,335 adults aged 20 to 74 years from the third National Health and Nutrition Examination Survey (NHANES III)
Comparison
Modified Cardiovascular-kidney-metabolic staging… vs Original CKM staging system based on the…
Design
Cohort
Follow-up
through 2019
Authors
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Integrating MAFLD into the CKM framework provides incremental improvement in prognostic discrimination for all-cause and cardiovascular mortality.
Cohort (n=10,335)
Yes
Does integrating MAFLD into the CKM framework improve mortality risk discrimination compared with the original CKM framework in adults?
Hazard Ratio: 3.84 (95% CI 3.38–4.37)
Integrating MAFLD into the CKM framework provides incremental improvement in prognostic discrimination for all-cause and cardiovascular mortality.
Mostafa et al. (2026) conducted a cohort in Cardiovascular-kidney-metabolic (CKM) syndrome (n=10,335). Modified CKM staging incorporating MAFLD vs. Original CKM framework was evaluated on All-cause mortality (HR 3.84, 95% CI 3.38-4.37). A modified CKM staging system incorporating MAFLD improved risk stratification for all-cause mortality compared to the original CKM system (HR 3.84; 95% CI 3.38-4.37 vs HR 3.49; 95% CI 3.07-3.95).
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