Synthetic study demonstrates visible-light phosphonylation without photocatalysts, indicating a sustainable route for late-stage alkyl phosphonate synthesis.
A visible-light-promoted phosphonylation of alkyl thianthrenium salts with phosphonites is achieved through an EDA-complex-mediated radical generation, enabling C(sp3)–P(V) bond formation under photocatalyst-free, mild conditions. The reaction exhibits broad substrate scope and applicability to late-stage modification of complex molecules, providing a practical and sustainable protocol for the synthesis of alkyl phosphonates.
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Chen et al. (2026) studied this question.
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