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September 14, 2026NeurophotonicsOpen Access

Metabolism and oxygen tension in Alzheimer’s disease mouse model using two-photon FLIM-PLIM microscopy

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Authors

VSVijay Kumar SagarHWHorst WallrabeSAShagufta Rehman Alam

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Overview

Preclinical study reveals elevated metabolic activity and decreased vascular oxygen tension in Alzheimer's disease mice, indicating increased cerebral oxygen consumption.

Key Points

  • To assess cerebral energy metabolism and microvascular oxygen tension in the cortex of an Alzheimer's disease mouse model compared to wild-type controls.
  • Conducted minimally invasive, simultaneous two-photon fluorescence and phosphorescence lifetime imaging (2P-FLIM-PLIM) in live, anesthetized Alzheimer's disease and wild-type mice.
  • Quantified mitochondrial metabolic activity via the protein-bound fraction of NAD(P)H and cerebrovascular partial pressure of oxygen (pO2) using the phosphorescent sensor Ru(BPY)3.
  • Alzheimer's disease mouse cortices exhibited elevated resting-state protein-bound NAD(P)H fractions compared with wild-type controls, reflecting altered mitochondrial metabolism.
  • Vascular oxygen tension was lower in Alzheimer's disease mice than in wild-type mice, indicating heightened resting-state cerebral oxygen consumption.

Cite This Study

Sagar et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b31b0926e14a848b1db7https://doi.org/10.1117/1.nph.13.3.035008
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