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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Investigating the Relation Between NAD+ Biosynthesis and Glucose Metabolism in a Mouse Model of Alzheimer's Disease using In Vivo 2H MRS

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Authors

NSNarayan Datt SoniASAnshuman SwainPJPaul Jacobs

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Overview

This research analyzes glucose metabolism and NAMPT levels in Alzheimer's mice, suggesting metabolic implications.

Key Points

  • Reduced glucose metabolism in Alzheimer's disease mice indicates compromised TCA cycle flux and NAD+ levels.
  • Labeling of 4,4-2H2-Glx showed reduced levels in AD mice, linking it to lower NAMPT activity and NAD+ synthesis.
  • The study utilized in vivo 2H MRS to monitor glucose metabolism and assess NAMPT levels in the mouse model.
  • This preliminary research highlights the potential of NAMPT activators to enhance neuroenergetics and glucose metabolism.

Cite This Study

Soni et al. (2025) studied this question.

synapsesocial.com/papers/68d45b0b31b076d99fa5cfdahttps://doi.org/10.58530/2025/4922
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