Key result
Severe propranolol intoxication presents unusually as acute psychosis preceding cardiovascular decompensation and seizures.
Why the study?
Although acute reversible psychosis has been observed with therapeutic propranolol dosing, this presentation had not been reported in beta blocker overdose or intoxication.
Case Report (n=1)
Severe propranolol intoxication can unusually present as an acute psychotic episode prior to cardiovascular decompensation, requiring a high index of suspicion.
Answers are grounded in this paper and cite their sources.
May prompt consideration of propranolol toxicity in unexplained psychosis; leaves open whether this represents a distinct prodrome needing validation.
Timely diagnosis of acute propranolol intoxication requires a high index of suspicion and a knowledge of the multiple ways in which these patients may present to the emergency department. We report a case of severe propranolol intoxication that presented as an acute psychotic episode preceding cardiovascular decompensation and seizures by several hours. Though acute reversible psychosis has been appreciated after initiating or increasing propranolol dosage therapeutically, this association has not been reported in the literature regarding beta blocker overdose or intoxication. Propranolol psychosis and several other pertinent aspects of this case are discussed.
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Love et al. (1995) conducted a case report in Propranolol intoxication (n=1). Propranolol intoxication was evaluated on Acute psychotic episode preceding cardiovascular decompensation and seizures. Severe propranolol intoxication can present unusually as an acute psychotic episode preceding cardiovascular decompensation and seizures.
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