Key result
Severe propranolol overdose of 4 g and 4.8 g in two women led to seizures and cardiogenic shock, resulting in one survival following intensive care and one fatality due to cardiac arrest.
Why the study?
Propranolol can be misused for suicide, leading to severe clinical manifestations ranging from neurological symptoms such as seizures to cardiogenic shock and death.
Case Report (n=2)
No
Propranolol overdose can lead to severe, life-threatening cardiogenic shock and neurological symptoms, emphasizing the need for rapid treatment initiation.
Raises awareness of propranolol overdose presentations in emergencies; leaves open questions on optimal management in severe β-blocker toxicity.
Propranolol, a β-blocker (BB), is one of the drugs that can be misused for suicide. The clinical manifestations of overdose can range from asymptomatic to neurological symptoms such as seizures and loss of consciousness, cardiac shock, and even death. Herein, we describe 2 cases that were referred to our hospital's emergency department in northern Iran: The first case was a 37-year-old woman who suffered from a decreased level of consciousness, bradycardia, and hypotension after ingesting 4 g of propranolol tablets. In the second case, a 32-year-old woman was admitted with complete cardiac arrest and a suspected history of ingesting 4.8 g of propranolol pills a few hours before admission. Therefore, the time interval between pill intake and treatment initiation seems to be one of the most important factors in prognosis, in addition to the number and dosage of pills ingested.
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Sharifpour et al. (2022) conducted a case report in Propranolol poisoning (n=2). Propranolol overdose was evaluated on Clinical outcome. Severe propranolol overdose of 4 g and 4.8 g in two women led to seizures and cardiogenic shock, resulting in one survival following intensive care and one fatality due to cardiac arrest.
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