Key result
Administration of an emetic compound in two patients with propranolol overdose resulted in cardiovascular collapse, likely due to vagal activity in the presence of sympathetic beta-blockade.
Why the study?
Does administration of an emetic compound precipitate cardiovascular collapse in patients with propranolol overdose?
Case Report (n=2)
Does administration of an emetic compound precipitate cardiovascular collapse in patients with propranolol overdose?
Emetic compounds may precipitate cardiovascular collapse in propranolol overdose, prompting a recommendation for prophylactic atropine.
May precipitate collapse in propranolol overdose; hypothesis-generating for atropine pretreatment.
We report three cases of propranolol overdose in two patients, both of whom suffered cardiovascular collapse after receiving an emetic compound in a hospital's casualty department. Such a collapse may be caused by vagal activity in the presence of sympathetic beta-blockade. We recommend the administration of atropine, which may increase vagal tone, before a patient receives an emetic compound, or undergoes gastric lavage or endotracheal intubation.
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Soni et al. (1983) conducted a case report in Propranolol overdose (n=2). Emetic compound was evaluated on Cardiovascular collapse. Administration of an emetic compound in two patients with propranolol overdose resulted in cardiovascular collapse, likely due to vagal activity in the presence of sympathetic beta-blockade.
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