Key result
Propranolol intoxication (2.28 g) in a 24-year-old man revealed a typical coved-type ECG pattern of Brugada syndrome, illustrating the possible deleterious effects of beta-blockers in this condition.
Why the study?
Does propranolol intoxication reveal Brugada syndrome in a healthy young man?
Case Report (n=1)
Does propranolol intoxication reveal Brugada syndrome in a healthy young man?
This case report illustrates that high concentrations of propranolol can reveal Brugada syndrome, highlighting the potential deleterious effects of beta-blockers in these patients.
Answers are grounded in this paper and cite their sources.
Propranolol overdose may unmask Brugada pattern; leaves open beta-blocker risks in confirmed cases.
This is the first report of Brugada syndrome revealed by beta-blocker intoxication. A 24-year-old healthy man ingested propranolol (2.28 g) to commit suicide. After early gastric lavage, electrolytes, cardiac enzymes, chest X-ray, and echocardiography were normal. Dosages of psychotropic drugs were negative. ECG showed a typical coved-type pattern of Brugada syndrome. Follow-up showed partial ECG normalization of the discrete saddleback-type pattern. The ajmaline- test confirmed Brugada syndrome. These ECG modifications may be explained by the stabilizing membrane effect of high concentration of propranolol and/or inhibition of ICaL. This case illustrates the possible deleterious effects of beta-blockers in patients with Brugada syndrome.
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Aouate et al. (2005) conducted a case report in Brugada syndrome (n=1). Propranolol intoxication was evaluated on ECG pattern of Brugada syndrome. Propranolol intoxication (2.28 g) in a 24-year-old man revealed a typical coved-type ECG pattern of Brugada syndrome, illustrating the possible deleterious effects of beta-blockers in this condition.
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