Key result
Stopping high-dose propofol resolves Brugada ECG pattern without arrhythmic sequelae in a critically ill patient.
Why the study?
Brugada ECG patterns have been reported in critically ill patients receiving propofol and are associated with high imminent mortality, but recovery after discontinuation is not well documented.
Case Report (n=1)
Prompt recognition and discontinuation of propofol in patients developing a propofol-associated Brugada ECG pattern can lead to complete resolution and prevent fatal arrhythmias.
May support vigilance for propofol-related Brugada patterns; leaves open need for prospective validation.
Brugada syndrome is a genetic disorder associated with an increased risk of sudden cardiac death that has typical electrocardiographic (ECG) patterns. Recently, there have been reports of Brugada ECG patterns seen in critically ill patients who received propofol,(1) and this pattern was associated with a very high imminent mortality. We report a case in which a critically ill patient developed a Brugada ECG pattern following high-dose propofol infusion. Once the ECG pattern was recognized, the propofol was discontinued and the ECG pattern resolved, and the patient was discharged home with no arrhythmic sequelae.
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Weiner et al. (2009) conducted a case report in Propofol-associated Brugada ECG pattern (n=1). High-dose propofol infusion was evaluated on Resolution of ECG pattern. Discontinuation of high-dose propofol in a critically ill patient with a propofol-associated Brugada ECG pattern led to resolution of the pattern and discharge without arrhythmic sequelae.
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