Key result
Correcting hyperkalemia reverses an induced Brugada ECG pattern to normal baseline rhythm.
Why the study?
Certain abnormalities, such as electrolyte disturbances, can precipitate a reversible Brugada pattern on ECG known as Brugada Phenocopy.
Case Report (n=1)
Highlights that severe hyperkalemia can induce a Brugada pattern on ECG (Brugada phenocopy) which resolves upon correction of the electrolyte abnormality.
Electrolyte correction may resolve Brugada-like ECG changes; this case report leaves open whether it alters clinical management.
Brugada Syndrome is a potentially fatal, hereditary cardiac disorder that may precipitate sudden cardiac death if not identified. An electrocardiogram (ECG) revealing a characteristic coved ST segment elevation followed by negative T wave in a right-sided precordial lead is pathognomonic for the Brugada pattern. Recently it has been shown that certain abnormalities, such as an electrolyte disturbance, may precipitate a Brugada pattern on ECG. Once the precipitating factor is treated, the rhythm reverts to baseline, coining the term Brugada Phenocopy. Here we present a captivating case of a 40-year-old female who was found unresponsive and determined to have a Brugada pattern on ECG secondary to hyperkalemia. Once appropriately treated, ECG reverts to normal baseline.
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Rezkalla et al. (2025) conducted a case report in Hyperkalemia-induced Brugada Phenocopy (n=1). Hyperkalemia was evaluated on Reversion of Brugada pattern to normal baseline ECG. Hyperkalemia induced a Brugada pattern on ECG in a 40-year-old female, which successfully reverted to a normal baseline rhythm upon appropriate treatment of the electrolyte disturbance.
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