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September 14, 2026Hepatic OncologyOpen Access

Racial and ethnic survival disparities in primary liver cancer in the United States: a National Cancer Database propensity score-matched study

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Authors

MÖMuhammet ÖzerSGSuleyman Y. GoksuAJAmy L. Jones

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Overview

Retrospective cohort study finds primary liver cancer survival disparities between Black and White patients attenuate after adjustment, highlighting the impact of treatment and access barriers.

Key Points

  • Evaluate whether racial and ethnic survival disparities among US patients diagnosed with primary liver cancer persist after adjusting for clinical, treatment, socioeconomic, and access-related variables.
  • Analyzed records of 122,049 patients diagnosed with primary liver cancer between 2004 and 2016 using the National Cancer Database.
  • Assessed overall survival across non-Hispanic White, non-Hispanic Black, and Hispanic groups using Kaplan–Meier analysis, log-rank tests, and multivariable Cox regression.
  • Performed 1:1 propensity score matching to balance baseline clinical, socioeconomic, and treatment factors between White and Black patients.
  • Black patients more frequently presented with advanced-stage liver cancer and received surgery, chemotherapy, or radiotherapy less often than White patients.
  • Following 1:1 propensity score matching, race was not an independent predictor of overall survival between White and Black patients (HR 0.98, p = 0.11).
  • Hispanic ethnicity was independently associated with improved overall survival compared with non-Hispanic White (HR 1.32, p < 0.001) and non-Hispanic Black patients (HR 1.29, p < 0.001).

Cite This Study

Özer et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3aa0926e14a848b2bcahttps://doi.org/10.1080/20450923.2026.2731867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial and ethnic disparities in survival among patients with early-onset primary liver cancer: A 15-year SEER analysis.2026
  2. 2Survival disparities among racial groups with hepatic malignant tumors2024 · 1 citations
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