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September 14, 2026Journal of Chemical & Engineering Data

Solubility Measurement, Correlation, Hansen Solubility Parameters, and Solvent Effect of 4-Isopropylbenzoic Acid in Twelve Pure Solvents at Temperatures from 278.15 to 323.15 K

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Authors

YSYanmin ShenJZJigang ZhangWWWanying Wu

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Overview

Experimental thermodynamic study demonstrates temperature-dependent solubility of 4-isopropylbenzoic acid across twelve solvents, highlighting predictive models for chemical processing.

Key Points

  • To measure the solid-liquid equilibrium solubility of 4-isopropylbenzoic acid across twelve pure organic solvents at various temperatures and evaluate predictive thermodynamic models.
  • Measured solubility in twelve pure solvents over temperatures ranging from 278.15 to 323.15 K under atmospheric pressure using the gravimetric method.
  • Correlated experimental solubility data using the modified Apelblat, van’t Hoff, and Yaws equations.
  • Assessed dissolution behavior and miscibility using Hansen solubility parameters and solvent effect analysis.
  • Solubility exhibited a strong positive correlation with temperature across all twelve pure solvents.
  • Mole fraction solubility at 298.15 K followed the order: DMF (0.4498) > 2-propoxyethanol (0.2474) > 2-butoxyethanol (0.2382) ≈ 2-ethoxyethanol (0.2371) > 2-methoxyethanol (0.2242) > ethyl acetate (0.1801) > methyl acetate (0.1461) > isobutyl acetate (0.1391) > propyl acetate (0.1231) ≈ butyl acetate (0.1202) > isopropyl acetate (0.1114) > acetonitrile (0.02216).
  • Experimental solubility data aligned closely with values calculated by the modified Apelblat, van’t Hoff, and Yaws thermodynamic models.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3bf0926e14a848b2df0https://doi.org/10.1021/acs.jced.6c00395
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