What does this research mean for the field?

Emerging pharmacological strategies for Chagas disease, including drug repurposing, novel molecular targets disrupting redox homeostasis, and combination therapies, offer promising alternatives to overcome the limitations and toxicities of standard acute-phase treatments. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review current pharmacological approaches and identify emerging therapeutic strategies and molecular targets for the treatment of Chagas disease.

September 14, 2026Revista Colombiana de Ciencias Químico FarmacéuticasOpen Access

Current landscape and future perspectives in Chagas disease chemotherapy: From nitroderivatives to new molecular targets

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Authors

FJFRANCISCO PATRICIO DE ANDRADE JÚNIORUniversidade Federal da Paraíba AMAna Karina Holanda Leite MaiaUniversidade Federal da Paraíba RFRafael Gomes FirminoUniversidade Estadual da Paraíba

Discussion

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Implication

Narrative review highlights emerging molecular targets and combination therapies in Chagas disease, suggesting novel pathways to overcome drug toxicity and parasite persistence.

Key Points

To review current pharmacological approaches and identify emerging therapeutic strategies and molecular targets for the treatment of Chagas disease.
Conducted a narrative literature review across PubMed, SciELO, and LILACS databases.
Critically analyzed studies focusing on Trypanosoma cruzi mechanisms of action, drug repurposing strategies, and novel pharmacological targets.
Standard nitroderivatives, benznidazole and nifurtimox, exhibit clear clinical efficacy mainly during the acute phase, whereas agents like posaconazole, TAK-187, and ravuconazole show therapeutic activity in preclinical models.
Repurposed agents such as flucofuron and targets driving redox homeostasis collapse and apoptosis-like mitochondrial dysfunction represent promising avenues for parasite clearance.
Combining benznidazole with the novel compound 1k in 3D cardiac microtissue models effectively controlled parasite infection while substantially reducing host cellular toxicity.

Cite This Study

JÚNIOR et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3df0926e14a848b31cd https://doi.org/10.15446/rcciquifa.v55n3.129592

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Implication

Narrative review highlights emerging molecular targets and combination therapies in Chagas disease, suggesting novel pathways to overcome drug toxicity and parasite persistence.

Current landscape and future perspectives in Chagas disease chemotherapy: From nitroderivatives to new molecular targets

Discussion

Member takes

Implication

Key Points

Cite This Study

Current landscape and future perspectives in Chagas disease chemotherapy: From nitroderivatives to new molecular targets

Discussion

Member takes

Implication

Key Points

Cite This Study

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