What does this research mean for the field?

Elevated serum uric acid is independently associated with early-stage renal impairment in patients with type 2 diabetes mellitus. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the relationship between serum uric acid levels and estimated glomerular filtration rate and determine if serum uric acid independently associates with stage 2 chronic kidney disease in type 2 diabetes mellitus patients.

September 14, 2026Discover MedicineOpen Access

Serum uric acid as an independent associated factor of early-stage renal impairment in patients with type 2 diabetes mellitus: a comparative cross-sectional study

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To evaluate the relationship between serum uric acid levels and estimated glomerular filtration rate and determine if serum uric acid independently associates with stage 2 chronic kidney disease in type 2 diabetes mellitus patients.
Conducted a hospital-based comparative cross-sectional study in 200 participants, comprising 100 type 2 diabetes mellitus patients and 100 age- and sex-matched healthy controls.
Measured biochemical parameters (serum uric acid, HbA1c, fasting blood glucose, lipid profile) and calculated eGFR using the race-free CKD-EPI equation.
Performed Pearson's correlation and multivariable linear regression adjusting for age, sex, BMI, HbA1c, diabetes duration, blood pressure, lipid profile, and proteinuria.
Serum uric acid levels were significantly higher in type 2 diabetes patients than in healthy controls (7.4 ± 1.5 vs. 4.8 ± 1.1 mg/dL; p < 0.001), alongside a mean diabetic eGFR of 79.3 ± 13.1 mL/min/1.73 m².
Serum uric acid demonstrated a significant negative correlation with eGFR (r = -0.44, p < 0.01).
Multivariable linear regression identified serum uric acid as an independent predictor of decreased eGFR (β = -0.38, p < 0.001) after adjusting for multiple cardiometabolic confounders.

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Implication

Cross-sectional study reveals elevated serum uric acid independently correlates with lower kidney filtration in type 2 diabetes, highlighting its utility for early renal decline detection.

Cite This Study

Yahya Ali Abdullah Alqadhi (2026) studied this question.

synapsesocial.com/papers/6aa7b42d0926e14a848b3bca https://doi.org/10.1007/s44337-026-00702-9

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Implication

Cross-sectional study reveals elevated serum uric acid independently correlates with lower kidney filtration in type 2 diabetes, highlighting its utility for early renal decline detection.

Serum uric acid as an independent associated factor of early-stage renal impairment in patients with type 2 diabetes mellitus: a comparative cross-sectional study

Key Points

Discussion

Implication

Cite This Study

Serum uric acid as an independent associated factor of early-stage renal impairment in patients with type 2 diabetes mellitus: a comparative cross-sectional study

Key Points

Discussion

Implication

Cite This Study

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