Key result
Targeting oxidative stress and inflammation offers potential therapeutic approaches for endothelial dysfunction-induced CVD.
Why the study?
The study was conducted to examine the data supporting the role of oxidative stress and inflammation in endothelial dysfunction-induced cardiovascular disease and atherosclerosis, as well as therapeutic approaches regulating ROS effects.
This review summarizes the mechanisms by which oxidative stress and inflammation drive endothelial dysfunction and atherogenesis, and discusses potential targeted therapeutic approaches.
Answers are grounded in this paper and cite their sources.
Should not yet change practice; leaves open whether genetic, phytochemical, or pharmaceutical targeting improves outcomes in endothelial dysfunction.
Studies have shown that the translation of endothelium from the quiescent to the activated state plays a significant role in the aetiology of cardiovascular disease and atherosclerosis.The presence of excess reactive oxygen species (ROS), either due to the presence of pro-oxidant agents or in the presence of risk factors such as diabetes, hyperlipidemia, smoke etc., has been implicated in endothelium activation with the consequent dysfunctioning of the endothelium.It has been shown that the nitric oxide (NO) synthesized by the endothelium nitric oxide synthase (eNOS) plays important role in maintaining endothelium integrity by modulating the vascular tone.The presence of excessive ROS can interact with the NO with consequent production of peroxynitrite to produce other ROS and pro-inflammatory cytokines in cascade-reactions.These, together with other risk factors have been implicated in ED-mediated cardiovascular disease.In this review, the data supporting the role of oxidative stress and inflammation in ED-induced cardiovascular disease and atherosclerosis was examined.Therapeutic approaches using genetics, phytochemicals and pharmaceuticals methods, in regulating the effects of ROS in ED-mediated cardiovascular morbidity and mortality and atherosclerosis were also examined.
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Lawal et al. (2022) conducted a review in Cardiovascular disease and atherosclerosis. Oxidative stress and inflammation was evaluated. Oxidative stress and inflammation play a significant role in endothelial dysfunction-induced cardiovascular disease, which may be targeted by genetic, phytochemical, and pharmaceutical approaches.
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