Key result
Non-diabetic ACS linked to a ~20% higher absolute incidence of impaired glucose tolerance versus controls.
Why the study?
The incidence of impaired glucose tolerance in non-diabetic patients with acute coronary syndrome and its impact on outcomes was not well established.
Does acute coronary syndrome increase the incidence of impaired glucose tolerance in non-diabetic patients?
Case-Control (n=50)
Does acute coronary syndrome increase the incidence of impaired glucose tolerance in non-diabetic patients?
Non-diabetic patients presenting with acute coronary syndrome have a significantly higher incidence of impaired glucose tolerance, which is associated with longer hospital stays and more complications.
May support glucose tolerance screening in non-diabetic ACS; hypothesis-generating for causality and outcome impact.
Background: Myocardial infarction, it still continues to be a major health problem worldwide. The aim of the study is to find out incidence of impaired glucose tolerance in non-diabetic patients with acute coronary syndrome. Methods: The study includes 50 patients. All the cases and controls were subjected to standard 75 gms. Oral Glucose Tolerance Test (OGTT) on admission, at the time of discharge and at three months follow-up and the observations were recorded. Results: Post prandial blood sugar at time 3 month follow up were 6 (12%) in cases and 9 (18%) in control but not significant statistically. There were 17 (34%) cases and 7 (14%) in control with IGT values which was statistically significant p= 0.034. Post prandial blood sugar at time of admission were 131.18 ± 21.52 in cases, 121.86 ± 21.47 in controls and at the time discharge in cases and controls were 139.10 ± 21.27 and 128.88 ± 9.44 respectively with p=0.003. Conclusion: Patients with acute coronary syndrome who have IGT on admission have longer hospital stay and more complications related to acute MI.
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Pandey et al. (2016) conducted a case-control in Acute Coronary Syndrome (n=50). Acute coronary syndrome vs. Controls was evaluated on Impaired glucose tolerance (IGT) (p=0.034). Non-diabetic patients with acute coronary syndrome had a significantly higher incidence of impaired glucose tolerance compared to controls (34% vs 14%, p=0.034).
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