The prognostic value of different glucose abnormalities in patients with acute myocardial infarction treated invasively
Key result
In patients with acute myocardial infarction treated with PCI, previously known diabetes (12.3%), new-onset diabetes (9.6%), and impaired glucose tolerance (9.4%) significantly increased long-term mortality compared to normal glucose tolerance (6.4%).
Why the study?
Do glucose abnormalities (IGT, new onset DM, known DM) increase long-term mortality in AMI patients treated with PCI compared to normal glucose tolerance?
Population
2733 consecutive acute myocardial infarction subjects treated with percutaneous coronary intervention…
Comparison
Glucose abnormalities vs Normal glucose tolerance (NGT)
Design
Cohort
Follow-up
mean 37.5 months
Authors
Discussion
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Member takes
Implication
Glucose abnormalities may warrant closer post-PCI AMI risk stratification; leaves open whether targeted intervention improves outcomes in this cohort.
Study Design
Type
Observational (n=2,527)
Multicenter
No
Structured PICO
Do glucose abnormalities (IGT, new onset DM, known DM) increase long-term mortality in AMI patients treated with PCI compared to normal glucose tolerance?
P
Population
2,527 consecutive patients with acute myocardial infarction treated with percutaneous coronary intervention, followed for a mean of 37.5 months to assess the prognostic impact of different glucose abnormalities.
E
Exposure
Glucose abnormalities (impaired fasting glycaemia [IFG], impaired glucose tolerance [IGT], previously known diabetes mellitus [DM], new onset DM)
C
Comparator
Normal glucose tolerance (NGT)
O
Outcome
Death rate during long-term follow-uphard clinical
Main Result
Absolute Event Rate: 12.3% vs 6.4%
p-value: p=<0.05
Impaired glucose tolerance and new-onset diabetes confer a similar long-term mortality risk as known diabetes in patients with AMI treated with PCI.
Limitations
- Single center, observational registry.
- Differences in baseline characteristics among study groups.
- OGTT was not repeated in the follow-up period.
- Details regarding further hypoglycaemic treatment are not available.
Cite This Study
Mazurek et al. (2012) conducted an observational in Acute myocardial infarction (n=2,527). Glucose abnormalities (diabetes, new-onset diabetes, impaired glucose tolerance) vs. Normal glucose tolerance was evaluated on Death from any cause (p=<0.05). In patients with acute myocardial infarction treated with PCI, previously known diabetes (12.3%), new-onset diabetes (9.6%), and impaired glucose tolerance (9.4%) significantly increased long-term mortality compared to normal glucose tolerance (6.4%).