Key result
Elevated HbA1c was an independent risk factor for posthospital mortality in AMI survivors with impaired glucose tolerance (HR 2.9; 95% CI 2.7-3.1) and newly detected diabetes (HR 1.53; 95% CI 1.39-1.66).
Why the study?
Does elevated HbA1c increase posthospital mortality in patients with AMI treated invasively and newly detected glucose abnormalities?
Population
2146 survivors of acute myocardial infarction treated invasively, specifically focusing on 457 patients with…
Comparison
Higher HbA1c levels vs Lower HbA1c levels
Design
Cohort
Authors
Loading...
Supports HbA1c monitoring for risk stratification in AMI survivors with new glucose abnormalities; leaves open whether intervention improves survival.
Cohort (n=2,146)
No
Does elevated HbA1c increase posthospital mortality in patients with AMI treated invasively and newly detected glucose abnormalities?
Hazard Ratio: 2.9 (95% CI 2.7–3.1)
Absolute Event Rate: 25% vs 4.5%
p-value: p=<0.001
Elevated HbA1c is a strong independent predictor of posthospital mortality in patients with AMI and newly diagnosed glucose abnormalities.
Kowalczyk et al. (2014) conducted a cohort in Acute myocardial infarction with newly detected glucose abnormalities (n=2,146). Elevated HbA1c (>5.9% in impaired glucose tolerance) vs. HbA1c ≤5.9% was evaluated on posthospital mortality in patients with impaired glucose tolerance (HR 2.9, 95% CI 2.7-3.1, p=<0.001). Elevated HbA1c was an independent risk factor for posthospital mortality in AMI survivors with impaired glucose tolerance (HR 2.9; 95% CI 2.7-3.1) and newly detected diabetes (HR 1.53; 95% CI 1.39-1.66).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: