What question did this study set out to answer?

To evaluate the efficacy of prophylactic tranexamic acid versus ε-aminocaproic acid or placebo in reducing perioperative blood product transfusion in orthotopic liver transplantation.

July 1, 2000Anesthesia & Analgesia

Tranexamic Acid Reduces Red Cell Transfusion Better than ε-Aminocaproic Acid or Placebo in Liver Transplantation

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To evaluate the efficacy of prophylactic tranexamic acid versus ε-aminocaproic acid or placebo in reducing perioperative blood product transfusion in orthotopic liver transplantation.
Prospective, double-blind randomized clinical trial involving 132 consecutive liver transplant recipients.
Patients received prophylactic tranexamic acid (10 mg·kg⁻¹·h⁻¹), ε-aminocaproic acid (16 mg·kg⁻¹·h⁻¹), or placebo (isotonic saline) under standardized perioperative management.
Intraoperative administration of packed red blood cells was significantly reduced in the tranexamic acid arm (P = 0.023), whereas ε-aminocaproic acid showed no significant reduction.
Postoperative transfusion requirements during the first 24 hours, thromboembolic events, reoperations, and mortality were similar across all three groups.

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Implication

Randomized double-blind trial demonstrates reduced red cell transfusion with tranexamic acid during liver transplantation, indicating superiority over aminocaproic acid.

Cite This Study

Dalmau et al. (2000) studied this question.

synapsesocial.com/papers/6aa7bfeaac18924c7657453f https://doi.org/10.1213/00000539-200007000-00006

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Implication

Randomized double-blind trial demonstrates reduced red cell transfusion with tranexamic acid during liver transplantation, indicating superiority over aminocaproic acid.

Tranexamic Acid Reduces Red Cell Transfusion Better than ε-Aminocaproic Acid or Placebo in Liver Transplantation

Key Points

Discussion

Implication

Cite This Study

Tranexamic Acid Reduces Red Cell Transfusion Better than ε-Aminocaproic Acid or Placebo in Liver Transplantation

Key Points

Discussion

Implication

Cite This Study

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