Key result
Calmodulin inhibitors induce rat smooth muscle relaxation by directly blocking Ca2+ channels.
Population
Smooth muscle from rat vas deferens (isolated cells and microsomal fraction)
Design
Preclinical
Authors
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Hypothesis-generating in rat tissue; leaves open whether Ca2+ blockade by calmodulin inhibitors translates to human smooth muscle.
Calmodulin inhibitors directly block voltage-gated Ca2+ channels in rat vas deferens smooth muscle, contributing to muscle relaxation.
Nakazawa et al. (1993) studied this question. Calmodulin inhibitors (trifluoperazine, W-7, calmidazolium) was evaluated on Ca2+ channel blockade and smooth muscle relaxation. Calmodulin inhibitors (trifluoperazine, W-7, and calmidazolium) directly block Ca2+ channels in rat vas deferens smooth muscle cells, which may be responsible for the observed muscle relaxation.
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