Key result
The mPAP-CO relationship for exercise-induced pulmonary hypertension may lack sensitivity to detect pulmonary vascular disease.
Why the study?
Exercise criteria for the diagnosis of pulmonary hypertension were removed from consensus guidelines due to lack of a suitable definition, but interest remains in defining abnormal pulmonary vascular response to exercise.
Does the mPAP-CO relationship provide adequate sensitivity for detecting exercise-induced pulmonary hypertension in patients with resting pulmonary hypertension?
Does the mPAP-CO relationship provide adequate sensitivity for detecting exercise-induced pulmonary hypertension in patients with resting pulmonary hypertension?
The mPAP-CO relationship may not be sensitive enough to properly define an abnormal pulmonary vascular response to exercise.
Combined criteria may refine exercise PH identification; leaves open outcome validation before guideline adoption.
Owing to the lack of a suitable definition, exercise criteria for the diagnosis of pulmonary hypertension (PH) were removed from consensus guidelines following the 4th World Pulmonary Hypertension Symposium in 2008 [1] and have remained absent following the 5th World Symposium [2] and recent European Cardiology Society/European Respiratory Society guidelines [3]. Nonetheless, there remains significant interest in properly defining an abnormal pulmonary vascular response to exercise [4–6]. Exercise-induced PH defined by the mPAP-CO relationship may lack sensitivity for detecting pulmonary vascular disease
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Mullin et al. (2017) studied Pulmonary hypertension. Exercise-induced PH criteria (mPAP-CO relationship) was evaluated. Exercise-induced pulmonary hypertension defined by the mPAP-CO relationship may lack sensitivity for detecting pulmonary vascular disease.
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