Key result
Evening hemodialysis linked to ~5% higher aortic augmentation index versus daytime hemodialysis.
Why the study?
Does evening hemodialysis compared to daytime hemodialysis increase arterial stiffness and cardiovascular complications in non-diabetic hemodialysis patients?
Cohort (n=20)
Does evening hemodialysis compared to daytime hemodialysis increase arterial stiffness and cardiovascular complications in non-diabetic hemodialysis patients?
Absolute Event Rate: 26% vs 21%
p-value: p=< 0.05
Evening hemodialysis is associated with higher aortic augmentation index (arterial stiffness) and potentially worse cardiovascular prognosis compared to daytime hemodialysis in non-diabetic patients.
Suggests hemodialysis timing may influence vascular stiffness; leaves open effects on cardiovascular outcomes pending prospective trials.
AIM: Cardiovascular disease constitutes a major cause of death in patients with chronic kidney diseases and is related to enhanced arterial stiffness. It has been reported that daytime hemodialysis patients show better prognosis than evening hemodialysis patients. METHODS: Aortic augmentation index (AI) and radial AI were measured in 20 non-diabetic hemodialysis patients, using SphygmoCor (PWV Medical) and HEM-9010AI (Omron Healthcare) as markers of arterial stiffness. Cardiovascular prognosis was followed for two years. RESULTS: Mean age, blood pressure, pulse rate, and aortic and radial AI were 52 +/- 4 y/o, 142 +/- 6/74 +/- 4 mmHg, 78 +/- 4 bpm, 21 +/- 2, and 71 +/- 4%, respectively, in 10 daytime hemodialysis patients, and they averaged 52 +/- 3 y/o, 146 +/- 6/76 +/- 4 mmHg, 74 +/- 3 bpm, 26 +/- 2, and 73 +/- 3% in 10 evening hemodialysis patients, respectively. Thus, aortic AI was higher in evening hemodialysis patients (p < 0.05). In all, one patient was hospitalized due to cardiovascular complications in daytime hemodialysis patients, as well as three patients from those dialyzed in the evening. CONCLUSION: Although a larger scale study is required to draw a definite conclusion, our findings suggest that a better prognosis in daytime hemodialysis non-diabetic patients is related to the lower AI.
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Takenaka et al. (2008) conducted a cohort in Hemodialysis (n=20). Evening hemodialysis vs. Daytime hemodialysis was evaluated on Aortic augmentation index (AI) (p=< 0.05). Evening hemodialysis was associated with a significantly higher aortic augmentation index compared to daytime hemodialysis (26% vs 21%, p < 0.05).
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