Key result
Thrombin reduces serum deprivation-induced apoptosis by ~70% in primary rodent myoblasts.
Absolute Event Rate: 15% vs 50%
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Hypothesis-generating for thrombin in myoblast survival; leaves open translation to human muscle repair or disease.
Chinni et al. (1999) studied Myoblast fusion and apoptosis. Thrombin vs. Absence of thrombin (control) was evaluated on Apoptosis within 24 h of serum deprivation. Thrombin treatment protected primary rodent myoblasts from serum deprivation-induced apoptosis, with <15% of treated cells showing apoptosis compared to 50% of control cells at 24 hours.
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