Commentary on Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes

A significant increase in pancreatic α-cells is observed in patients and animal models with recent-onset type 1 diabetes (T1D).Our recent studies suggest that the increase in α-cell proliferation in recent-onset T1D results, at least partially, from a decline of the paracrine factor γ-aminobutyric acid as a consequence of β-cell deficiency.