Key result
Cocaine dependence severity correlates with reduced left frontoparietal network modulation during monetary reward tasks.
Why the study?
Cocaine addiction is characterized by motivational and cognitive alterations, and this study aimed to investigate how cocaine addiction affected the left frontoparietal network during goal-directed behavior in a stop-signal task with reward contingencies.
How does cocaine addiction affect the left frontoparietal network during goal-directed behavior with reward contingencies?
Case-Control (n=58)
How does cocaine addiction affect the left frontoparietal network during goal-directed behavior with reward contingencies?
Cocaine dependence alters the modulation of the left frontoparietal network by monetary rewards during cognitive control tasks.
Answers are grounded in this paper and cite their sources.
Cocaine dependence may disrupt frontoparietal reward modulation during cognitive control; hypothesis-generating and should not yet change practice.
Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal-directed behavior in a stop-signal task (SST) with reward contingencies by correct task performance. Twenty-eight healthy controls (HC) and 30 abstinent cocaine-dependent patients (ACD) performed SST with monetary reward contingencies while undergoing a functional magnetic resonance imaging scan. The results showed that the left frontoparietal network (FPN) displayed an effect of cocaine addiction depending on reward contingencies rather than inhibition accuracy; and, second, we observed a negative correlation between dependence severity and the modulation of the left FPN network by the monetary reward in ACD. These findings highlight the role of the left FPN in the motivational effects of cocaine dependence.
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Barrós‐Loscertales et al. (2019) conducted a case-control in Cocaine addiction (n=58). Cocaine addiction vs. Healthy controls was evaluated on Modulation of the left frontoparietal network during goal-directed behavior in a stop-signal task with reward contingencies. Cocaine addiction altered left frontoparietal network activity depending on reward contingencies, and dependence severity negatively correlated with network modulation by monetary reward.
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