Key result
There was a poor direct correlation between HbA1c and Gensini score (r=0.0444), although ANOVA analysis suggested that better diabetes control is associated with a less severe acute coronary syndrome profile.
Why the study?
The relationship between glycemic control and the presence and severity of coronary artery disease in patients presenting clinically with acute coronary syndrome remained to be evaluated.
Is glycemic control correlated with the angiographic severity of coronary artery disease in patients with acute coronary syndrome?
Cohort (n=1,200)
No
Is glycemic control correlated with the angiographic severity of coronary artery disease in patients with acute coronary syndrome?
Effect estimate: r=0.0444
p-value: p=<0.001
In patients with acute coronary syndrome, while direct linear correlation is poor, better diabetes control is associated with a less severe angiographic profile of coronary artery disease.
Background: Aim of the study was to study relationship between Glycemic control and presence of coronary artery disease on clinical presentation with acute coronary syndrome (ACS). We used blood sugar levels (Fasting and post prandial) and HbA1c as parameter for evaluation of glycemic control, Gensini score was used as a parameter for evaluation of severity of coronary artery disease.Methods: The analysis of 1200 patient’s data were performed to reveal demographic characteristics, correlation of the diabetes control with severity of the ACS. A sub-set of 200 subjects that was collected with a focus to include diabetic and non-diabetic subjects in proportion 1:2 was performed.Results: The Pearson correlation between HbA1c and Gensini score (r=0.0444) was poor the correlation between fasting blood sugar (FBS) and Gensini score (r=0.0586), and between post prandial blood sugar (PPBS) and Gensini score (r=0.0549), between random blood sugar (RBS) and Gensini score (r=0.0331) all indicative of poor correlation. Duration of diabetes and Gensini score revealed r=-0.039. The. Correlation was poor to moderate with one sided ANOVA and consistent on comparing r-sq values between, HbA1c and Gensini Score [rsq=49.62 (p<0.001)], FBS and Gensini score [rsq=32.19 (p<0.001)], PPBS and Gensini score [rsq=25.39 (<0.001)], RBS and Gensini score [rsq=42.49 (p<0.001)] and duration of diabetes and Gensini score [rsq=19.61 (p<0.001)].Conclusions: There was no correlation evident between diabetes and Gensini dcore. The analysis was suggestive of possible strong relationship between diabetes control and IHD severity. There is no correlation between Diabetes and ACS severity. However, better diabetes control is related with better ACS profile.
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Parkar et al. (2021) conducted a cohort in Acute coronary syndrome (n=1,200). Glycemic status vs. Good glycemic control / Non-diabetic was evaluated on Correlation between HbA1c and Gensini score (r=0.0444, p=<0.001). There was a poor direct correlation between HbA1c and Gensini score (r=0.0444), although ANOVA analysis suggested that better diabetes control is associated with a less severe acute coronary syndrome profile.
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