Key result
Oral glucose load raises SBP and HR in normotensives but elicits blunted responses in primary hypertensives.
Why the study?
Does an oral glucose load affect insulinemia and blood pressure differently in primary hypertensive patients compared to normotensive controls?
Population
28 subjects (14 primary hypertensive patients and 14 normotensive control subjects)
Comparison
Oral glucose test vs Normotensive control subjects
Design
Case-control
Authors
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May signal insulin resistance subset in hypertension without practice change; leaves open mechanistic and prognostic roles pending prospective data.
Case-Control (n=28)
Does an oral glucose load affect insulinemia and blood pressure differently in primary hypertensive patients compared to normotensive controls?
A subset of primary hypertensive patients exhibits insulin resistance and a blunted cardiovascular response to an oral glucose load compared to normotensive individuals.
Elza Muscelli (2008) conducted a case-control in Primary hypertension (n=28). Oral glucose load vs. Normotensive control subjects was evaluated on Cardiovascular responses (blood pressure, pulse rate) and plasma potassium, glucose, and insulin levels. An oral glucose load elicited significant increases in systolic blood pressure and heart rate in normotensive subjects, but a smaller or absent response in primary hypertensive patients.
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