What question did this study set out to answer?

To investigate whether fasting insulin levels differ between primary and secondary hypertension and assess their relationship with elevated blood pressure and glucose metabolism.

July 1, 1990American Journal of Hypertension

Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment

View Full Paper

Ask AI

Bookmark

Why the study?

Is there a relationship between fasting insulinemia and blood pressure in patients with primary and secondary hypertension?

Population

117 untreated and newly diagnosed subjects, including 69 normotensive subjects, 36 with essential…

Comparison

Essential hypertension or renovascular… vs Normotensive subjects

Design

Cross-sectional

Authors

AMA MariglianoUniversity of Florence RTR TeddeUniversity of Sassari LSLeonardo Alberto SechiUniversity of Sassari

Discussion

Member takes

Implication

Insulin resistance may be specific to essential hypertension; leaves open whether it precedes or follows elevated blood pressure.

Key Points

To investigate whether fasting insulin levels differ between primary and secondary hypertension and assess their relationship with elevated blood pressure and glucose metabolism.
Assessed fasting insulinemia in 117 newly diagnosed, untreated subjects: 69 normotensive controls, 36 patients with essential hypertension, and 12 patients with renovascular hypertension.
Stratified subjects into four metabolic subgroups: euglycemic nonobese, euglycemic obese, impaired glucose tolerance, and non-insulin-dependent diabetes mellitus.
Fasting insulinemia was significantly higher in patients with essential hypertension compared with normotensive subjects (P < .0005) and remained higher across every subgroup (P < .05).
Fasting insulin levels in patients with renovascular hypertension were similar to those in normotensive controls.
A significant positive correlation occurred between fasting insulinemia and mean blood pressure in essential hypertension (r = 0.408, P < .05), but no correlation was observed in renovascular hypertension.

Structured PICO

Is there a relationship between fasting insulinemia and blood pressure in patients with primary and secondary hypertension?

Population

117 untreated and newly diagnosed subjects, including 69 normotensive subjects, 36 with essential hypertension, and 12 with renovascular hypertension, classified into subgroups (euglycemic nonobese, euglycemic obese, impaired glucose tolerance, and non-insulin-dependent diabetes mellitus).

Intervention

Essential hypertension or renovascular hypertension (observational exposure)

Comparator

Normotensive subjects

Outcome

Fasting insulinemia levelssurrogate

Fasting insulinemia is directly related to blood pressure in essential hypertension but not in renovascular hypertension, suggesting that elevated blood pressure itself does not cause an insulin-resistant state.

Cite This Study

Marigliano et al. (1990) studied this question.

synapsesocial.com/papers/6a6f7fce35aa2c282ce0db24 https://doi.org/10.1093/ajh/3.7.521

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider