Key result
Essential hypertension is independently associated with a decreased insulin metabolic clearance rate compared to normotensive subjects (328 vs 521 mL/min per m2; P<0.001).
Why the study?
Is essential hypertension associated with decreased insulin clearance independently of insulin resistance?
Population
75 subjects, comparable in terms of age, body fat content, waist-to-hip ratio, and sex distribution.
Comparison
Essential hypertension (observational exposure) vs Normotensive subjects
Design
Cross-sectional
Authors
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May explain hyperinsulinemia in hypertension; hypothesis-generating and requires prospective confirmation before clinical relevance.
Cross-Sectional (n=75)
Is essential hypertension associated with decreased insulin clearance independently of insulin resistance?
Absolute Event Rate: 328% vs 521%
p-value: p=<.001
Essential hypertension is independently associated with a decreased insulin metabolic clearance rate, which may contribute to the hyperinsulinemia observed in these patients.
Lender et al. (1997) conducted a cross-sectional in Essential hypertension (n=75). Essential hypertension vs. Normotensive subjects was evaluated on Insulin metabolic clearance rate (mL/min per m2) (p=<.001). Essential hypertension is independently associated with a decreased insulin metabolic clearance rate compared to normotensive subjects (328 vs 521 mL/min per m2; P<0.001).
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