Key result
Absence of symptoms during RVP linked to ~100% greater likelihood of asymptomatic first-onset AF.
Why the study?
Silent AF poses a risk of ischemic stroke, and a method is needed to predict the development of asymptomatic AF before stroke occurs.
Does the absence of symptoms during rapid ventricular pacing predict asymptomatic first-onset atrial fibrillation in pacemaker patients?
Population
145 pacemaker patients at the outpatient clinic
Comparison
Absence vs presence of symptoms during VVI pacing at 120 ppm
Design
Observational study
Authors
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Pacing symptom absence was associated with asymptomatic AF onset; hypothesis-generating in small cohort and needs prospective validation before any clinical use.
Observational (n=145)
No
Does the absence of symptoms during rapid ventricular pacing predict asymptomatic first-onset atrial fibrillation in pacemaker patients?
Relative Risk: 2 (95% CI 1.045–3.502)
Absolute Event Rate: 100% vs 50%
p-value: p=0.04
The absence of symptoms during rapid ventricular pacing in pacemaker patients is strongly associated with first-onset atrial fibrillation being asymptomatic, potentially identifying patients at risk for silent AF.
Matsubara et al. (2022) conducted an observational in Atrial Fibrillation in Pacemaker Patients (n=145). Absence of symptoms during rapid ventricular pacing vs. Presence of symptoms during rapid ventricular pacing was evaluated on First-onset atrial fibrillation being asymptomatic (RR 2.000, 95% CI 1.045-3.502, p=0.04). Absence of symptoms during rapid ventricular pacing was significantly associated with first-onset atrial fibrillation being asymptomatic (RR 2.000).
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