Key result
Deoxycholate Amphotericin-B linked to cardiomyopathy that reverses upon drug discontinuation in an AIDS patient.
Why the study?
Does stopping Deoxycholate Amphotericin-B and switching to Fluconazole reverse cardiomyopathy in a patient with AIDS and cryptococcal meningitis?
Does stopping Deoxycholate Amphotericin-B and switching to Fluconazole reverse cardiomyopathy in a patient with AIDS and cryptococcal meningitis?
Deoxycholate Amphotericin-B may cause reversible cardiomyopathy that resolves upon discontinuation of the drug.
Raises possibility of reversible deoxycholate amphotericin-B cardiomyopathy in AIDS; single case leaves causality and generalizability open.
We describe a 32-yr old woman with AIDS and cryptococcal meningitis that developed cardiomyopathy after 17 days of treatment with Deoxycholate Amphotericin-B (D-Amb) with reversal of the symptoms and transthoracic echocardiogram (TTE) findings after the drug had been stopped and switched to Fluconazole.
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Bandeira et al. (2016) studied this question. Deoxycholate Amphotericin-B induced cardiomyopathy after 17 days of treatment in a patient with AIDS, with symptoms and echocardiogram findings reversing upon drug discontinuation.
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