Key result
1-hour amphotericin B infusions show no link to new ventricular dysrhythmias versus baseline monitoring.
Why the study?
Does 1-hour infusion of amphotericin B induce ventricular dysrhythmias in patients with preserved renal function?
Observational (n=27)
Does 1-hour infusion of amphotericin B induce ventricular dysrhythmias in patients with preserved renal function?
1-hour infusions of amphotericin B up to 0.9 mg/kg do not appear to induce asymptomatic ventricular dysrhythmias in patients with preserved renal function.
May support 1-hour amphotericin B infusions without arrhythmia risk in preserved renal function; hypothesis-generating and requires randomized confirmation.
In order to assess the safety of 1-h infusions of amphotericin B (AMB), we prospectively monitored 213 1-h infusions of AMB (dose range, 0.27 to 0.89 mg/kg of body weight) in 27 patients with creatinine clearances of > 25 ml/min. Holter monitor tracings during 1-h infusions were compared with those during a 4-h baseline period of monitoring. There were no ventricular dysrhythmias during 1-h infusions of AMB that were not present during baseline monitoring. Nausea and/or rigors were noted for 32 (15%) infusions in six (22%) patients. No patient exhibited a temperature rise of > 1 degree C. We conclude that, in doses of up to 0.9 mg/kg, AMB does not appear to induce asymptomatic ventricular dysrhythmias when administered over 1 h to patients with creatinine clearances of > 25 ml/min.
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Bowler et al. (1992) conducted an observational in Preserved renal function requiring amphotericin B (n=27). 1-hour infusions of amphotericin B vs. 4-hour baseline period of monitoring was evaluated on Ventricular dysrhythmias not present during baseline monitoring. 1-hour infusions of amphotericin B (up to 0.89 mg/kg) did not induce new ventricular dysrhythmias compared to baseline monitoring in patients with creatinine clearance > 25 ml/min.
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