Why the study?
Does rapid infusion of amphotericin B increase the risk of hyperkalemia and ventricular fibrillation in patients with impaired renal function?
Population
11 patients with disseminated fungal infections, including 3 anuric patients and 8 patients with normal…
Comparison
Rapid intravenous infusion of amphotericin B. vs Prolonged amphotericin B infusion or concurrent…
Design
Case_series
Follow-up
Up to 72 hours post-infusion
Authors
Loading...
Rapid amphotericin B infusion warrants caution in anuric patients; this single case leaves open optimal protocols and broader applicability.
Does rapid infusion of amphotericin B increase the risk of hyperkalemia and ventricular fibrillation in patients with impaired renal function?
Rapid infusion of amphotericin B in anuric patients can cause life-threatening hyperkalemia and ventricular fibrillation, necessitating concurrent hemodialysis, prolonged infusion times, and careful potassium monitoring.
Craven et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: