A three-dimensional (3D) finite element electromechanical model of the heart is employed in simulations of seismocardiograms (SCGs). To simulate SCGs, a previously developed 3D model of ventricular contraction is extended by adding the mechanical interaction of the heart with the chest and internal organs. The proposed model reproduces the major peaks of seismocardiographic signals during the phases of the cardiac cycle. Results indicate that SCGs record the pressure of the heart acting on the ribs. In addition, the model reveals that the rotation of the rib with respect to the heart has a minor effect on seismocardiographic signal morphology during the respiratory cycle. SCGs are obtained from 24 human volunteers and their morphology is analyzed. Experimental results demonstrate that the peak of the maximum acceleration of blood in the aorta occurs at the same time as the global minimum of the SCG. It is confirmed that the first SCG peak after the electrocardiogram R-wave corresponds to aortic valve opening, as determined from the impedance cardiogram (p = 0.92). The simulation results reveal that the SCG peaks corresponding to aortic valve opening and the maximum acceleration of blood in the aorta result from ventricular contraction in the longitudinal direction of the ventricles and a decrease in the dimensions of the ventricles due to the ejection of blood, respectively.