Key result
Higher hypnotizability is linked to strongly correlated changes in ABP and MCA velocity during hyperventilation.
Why the study?
Hypnotizability is associated with differences in brachial artery flow-mediated dilatation, prompting investigation into possible hypnotizability-related cerebrovascular differences.
Does hypnotizability score influence cerebrovascular and hemodynamic responses to cognitive and respiratory tasks in healthy subjects?
Observational (n=24)
No
Does hypnotizability score influence cerebrovascular and hemodynamic responses to cognitive and respiratory tasks in healthy subjects?
Effect estimate: ρ = 0.842
p-value: p=0.002
Hypnotizability scores are associated with distinct patterns of cerebrovascular reactivity and hemodynamic correlations during cognitive and respiratory tasks.
No immediate clinical implications for cerebrovascular assessment; leaves open associations in larger or clinical cohorts.
Hypnotizability is a cognitive trait associated with differences in the brachial artery flow-mediated dilatation of individuals with high hypnotizability (highs) and low hypnotizability scores (lows). The study investigated possible hypnotizability-related cerebrovascular differences. Among 24 healthy volunteers, the Stanford Hypnotic Susceptibility Scale Form A identified 13 medium-to-lows (med-lows), 11 medium-to-highs (med-highs), and 1 medium hypnotizable. Hypnotizability did not influence the significant changes produced by the trail making task (TMT), mental arithmetic task (MAT), hyperventilation (HVT), and rebreathing (RBT) on heart rate (HR), arterial blood pressure (ABP), and partial pressure of end-tidal CO2 (PETCO2), but moderated the correlations between the changes occurring during tasks with respect to basal conditions (Δ) in ABP and PETCO2 with middle cerebral artery flow velocity (MCAv). In HVT, med-lows exhibited a significant correlation between ΔMCAv and ΔPETCO2, and med-highs showed a significant correlation between ΔABP and ΔMCAv. Cerebrovascular reactivity (CVR) and conductance (ΔCVCi) were significantly correlated with ΔMCAv only in med-lows during HVT and RBT. For the first time, cerebrovascular reactivity related to hypnotizability was investigated, evidencing different correlations among hemodynamic variables in med-highs and med-lows.
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Rashid et al. (2022) conducted an observational in Healthy subjects (n=24). Hypnotizability score (medium-high vs medium-low) vs. Medium-low hypnotizability was evaluated on Correlation between changes in middle cerebral artery flow velocity (ΔMCAv) and arterial blood pressure (ΔABP) during hyperventilation (ρ = 0.842, p=0.002). In healthy subjects, hypnotizability moderated cerebrovascular responses during hyperventilation, with medium-high hypnotizable individuals showing a significant correlation between changes in arterial blood pressure and middle cerebral artery flow velocity (ρ = 0.842, p = 0.002).
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