Key result
Hypnotizability moderates how blood pressure and CO2 changes correlate with MCAv during respiratory tasks.
Why the study?
Hypnotizability is associated with differences in brachial artery flow-mediated dilatation, prompting investigation into possible hypnotizability-related cerebrovascular differences.
Does hypnotizability level affect cerebrovascular responses to cognitive and respiratory tasks in healthy volunteers?
Observational (n=24)
Does hypnotizability level affect cerebrovascular responses to cognitive and respiratory tasks in healthy volunteers?
Hypnotizability levels are associated with different physiological mechanisms controlling middle cerebral artery flow velocity and cerebrovascular reactivity during hyperventilation and rebreathing.
Hypnotizability may not extend to cerebrovascular function; leaves open bed-specific vascular effects in this small healthy cohort.
Hypnotizability is a cognitive trait associated with differences in the brachial artery flow-mediated dilatation of individuals with high hypnotizability (highs) and low hypnotizability scores (lows). The study investigated possible hypnotizability-related cerebrovascular differences. Among 24 healthy volunteers the Stanford Hypnotic Susceptibility Scale Form A, identified 13 medium-to-lows (med-lows), 11 medium-to-highs (med-highs), 1 medium hypnotizable. Hypnotizability did not influence the significant changes produced by the trail making task (TMT), mental arithmetic task (MAT), hyperventilation (HVT) and rebreathing (RBT) on Heart rate (HR), arterial blood pressure (ABP) and partial pressure of end-tidal CO2 (PETCO2) and oxygenation (TOI); but moderated the correlations between the changes occurring during tasks with respect to basal conditions (Δ) in ABP and PETCO2 with MCAv. In HVT, med-lows exhibited a significant correlation between ΔMCAv and ΔPETCO2, med-highs showed a significant correlation between ΔABP and ΔMCAv; a significant correlation between ΔTHI and ΔTOI was observed in medium lows. Cerebrovascular reactivity (CVR) and conductance (ΔCVCi) were significantly correlated with ΔMCAv in med-lows during HVT and RBT. Findings represent the first assessment of hypnotizability-related differences in the mechanisms controlling the middle cerebral artery flow velocity, cerebrovascular reactivity and conductance in response to hyperventilation and rebreathing.
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Rashid et al. (2022) conducted an observational in Healthy volunteers (n=24). High hypnotizability vs. Low hypnotizability was evaluated on Cerebrovascular differences (changes in MCAv, ABP, PETCO2) during tasks. Hypnotizability moderated the correlations between changes in arterial blood pressure and end-tidal CO2 with middle cerebral artery flow velocity during tasks such as hyperventilation.
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