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ARIOUS chemotherapeutic agents have been investigated relative to their influence on experimental and natural chronic respiratory disease (CRD) infection. Results obtained from in vitro, in ovo, and in vivo studies have been extremely variable. Olesiuk et al. have recently reviewed the literature on this subject. Yamamoto and Adler6 and Hamdy et al.l reported chlortetracycline (CTC) and oxytetracycline (OTC) among the most active antibiotics in their in vitro studies with CRD.
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Olesiuk et al. (1959) studied this question.
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