Key result
Serum ET-1 is linked to higher systolic and pulse pressures in black South African women.
Why the study?
Limited data exist regarding endothelin-1 and its association with arterial stiffness markers in populations subjected to early vascular deterioration.
Is endothelin-1 associated with markers of arterial stiffness in black and white South Africans?
Cross-Sectional (n=392)
Is endothelin-1 associated with markers of arterial stiffness in black and white South Africans?
Effect estimate: β = 0.28
p-value: p=< 0.01
Endothelin-1 is independently associated with markers of arterial stiffness (systolic and pulse pressure) specifically in black South African women, potentially linked to low-grade inflammation.
No immediate clinical implications; leaves open endothelin-1's causal role in arterial stiffness among black South African women.
Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n = 99; women: n = 95) and 197 white (men: n = 99; women: n = 98) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. R (2) = 0.13; β = 0.28, p < 0.01) and pulse pressure (Adj. R (2) = 0.11; β = 0.27, p < 0.01) was confirmed in black women only. ET-1 additionally associated with interleukin-6 in black women (p < 0.01). Conclusion. Our result suggests that ET-1 and its link with subclinical arteriosclerosis are potentially driven by low-grade inflammation as depicted by the association with interleukin-6 in the black female cohort.
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Plooy et al. (2015) reported a cross-sectional. Endothelin-1 (ET-1) was evaluated on Systolic blood pressure (β = 0.28, p=< 0.01). Serum endothelin-1 levels were independently associated with systolic blood pressure (β=0.28, p<0.01) and pulse pressure (β=0.27, p<0.01) in black South African women.
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