Key result
COVID-19 in ACS is linked to ~39% in-hospital mortality and increased need for MCS.
Why the study?
To describe the clinical characteristics and angiographic features of COVID-19 patients presenting with ACS and compare them with concurrent non-COVID-19 ACS patients.
Does COVID-19 infection alter the clinical and angiographic characteristics or in-hospital outcomes of patients presenting with acute coronary syndrome?
Case-Control (n=4,107)
No
Does COVID-19 infection alter the clinical and angiographic characteristics or in-hospital outcomes of patients presenting with acute coronary syndrome?
Absolute Event Rate: 38.8% vs 1.3%
p-value: p=<0.001
Patients with concurrent COVID-19 and acute coronary syndrome frequently present with STEMI and exhibit sub-optimal angiographic TIMI flow grades.
Supports vigilant ACS management with COVID-19; leaves open causal mechanisms and optimal interventions.
Objectives: To describe the clinical characteristics and angiographic features of COVID-19 patients presenting with acute coronary syndrome (ACS) and to compare with non-COVID-19 ACS patients presenting simultaneously. Methodology: In a case control design, data were extracted from a prospectively collected COVID-19 and NCDR registry. All ACS patients who underwent cardiac catheterization from April 2020 to May 2021 were included. All of the patients were taken to the Cath lab for diagnostic coronary angiography and possible percutaneous intervention. Demographic and clinical characteristics, angiographic features, and in-hospital outcomes were compared between ACS patients with and without COVID-19. Results: A total of 4027 COVID-19 negative patients, and 80 COVID-19 positive were included. Total of 83% in COVID-19 and 88% in non-COVID-19 group had ST elevation myocardial infarction. Majority of the COVID-19 positive patients had sub-optimal TIMI flow grade (
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Ammar et al. (2023) conducted a case-control in Acute Coronary Syndrome (n=4,107). COVID-19 infection vs. Non-COVID-19 patients was evaluated on In-hospital mortality (p=<0.001). COVID-19 infection in patients presenting with acute coronary syndrome was associated with significantly higher in-hospital mortality (38.8% vs 1.3%) and increased need for mechanical circulatory support.
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