Key result
Antithrombotic therapy increases bleeding complications ~8-fold in patients undergoing cholecystectomy.
Why the study?
The study was conducted to assess evidence on the safety of cholecystectomy in patients under antithrombotic therapy.
Does concomitant antithrombotic therapy increase bleeding complications in patients undergoing cholecystectomy?
Meta-Analysis
Does concomitant antithrombotic therapy increase bleeding complications in patients undergoing cholecystectomy?
The use of antithrombotic therapy in patients undergoing cholecystectomy is associated with significantly increased risks of bleeding complications, blood transfusions, and conversion to open surgery.
Supports safe cholecystectomy on antithrombotics; extends observational evidence but warrants randomized confirmation.
Objective: This review aimed to assess evidence on the safety of cholecystectomy in patients under antithrombotic therapy. Methods: PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched from inception up to 20th January 2022 for studies comparing outcomes of patients undergoing cholecystectomy surgeries with or without concomitant antithrombotic therapy. Results: Nine studies were included. Meta-analysis revealed that the use of antithrombotic medications had no statistically significant effect on intra-operative blood loss in patients undergoing cholecystectomy (MD: 82.31 95% CI: -283.38, 448 I2=98% p=0.66). However, incidence of blood transfusion (OR: 5.65 95% CI: 1.10, 28.86 I2=83% p=0.04) and bleeding complications (OR: 8.02 95% CI: 1.71, 37.58 I2 = 71% p=0.008) were significantly increased in patients under antithrombotic therapy. Pooled analysis indicated that cholecystectomy patients under antithrombotic are at an increased risk of conversion to open surgery (OR: 2.02 95% CI: 1.21, 3.36 I2=0% p=0.007). Meta-analysis revealed significantly shorter LOS in patients under antithrombotic (MD: -5.01 95% CI: -8.29, -1.73 I2=97% p=0.03). Conclusion: Current evidence from a limited number of studies indicates that the use of antithrombotic may be associated with an increased risk of bleeding-related complications in patients undergoing cholecystectomies. Antithrombotic use may also increase the risk of conversion to open surgery in patients undergoing laparoscopic cholecystectomies. doi: https://doi.org/10.12669/pjms.38.8.7032 How to cite this:Shao X, Cui X. Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis. Pak J Med Sci. 2022;38(8):2365-2372. doi: https://doi.org/10.12669/pjms.38.8.7032 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
No takes yet. Share an insight, caveat, or question.
Shao et al. (2022) conducted a meta-analysis in Cholecystectomy. Antithrombotic therapy vs. No antithrombotic therapy was evaluated on Bleeding complications (OR 8.02, 95% CI 1.71, 37.58, p=0.008). Antithrombotic therapy significantly increased the risk of bleeding complications (OR 8.02) in patients undergoing cholecystectomy compared to those not receiving antithrombotics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: