Key result
In patients with atrial fibrillation, left atrial remodeling leads to mitral annulus expansion, reduced contractility, and atriogenic posterior mitral leaflet tethering, which aggravates functional mitral regurgitation.
Why the study?
Understanding the mechanisms underpinning mitral regurgitation in AF patients is crucial to optimize therapeutic strategies.
Does high volume rate 3D-TEE identify distinct morphological mechanisms of mitral regurgitation in atrial fibrillation patients with and without ventricular dysfunction?
Observational (n=104)
Single-blind
No
Does high volume rate 3D-TEE identify distinct morphological mechanisms of mitral regurgitation in atrial fibrillation patients with and without ventricular dysfunction?
High volume rate 3D-TEE reveals that atrial functional mitral regurgitation is driven by left atrial remodeling causing mitral annulus expansion, reduced contractility, and atriogenic posterior mitral leaflet tethering, which is further exacerbated by left ventricular dysfunction.
High-volume 3D-TEE may delineate atrial functional MR mechanisms in AF; leaves open validation and therapeutic impact in prospective studies.
Aims Meticulous understanding of the mechanisms underpinning mitral regurgitation in atrial fibrillation (AF) patients is crucial to optimize therapeutic strategies. The morphologic characteristics of mitral valves in atrial functional mitral regurgitation (FMR) patients with and without left ventricular (LV) dysfunction were evaluated by high volume rate (HVR) three-dimensional transesophageal echocardiography (3D-TEE).Methods and results Of 265 AF patients who underwent 3D-TEE, 68 were retrospectively selected, including 36 patients with AF, FMR, and preserved LV function (AFMR group) and 32 patients with AF, FMR, and LV dysfunction (VFMR group). In addition, 36 fever patients without heart disease were included in the control group. The left atrium (LA) was enlarged in the AFMR and VFMR groups compared with the control group. The mitral annulus (MA) in the AFMR group was enlarged and flattened compared with the control group and was smaller than in the VFMR group. The annulus area fraction was significantly diminished in the AFMR and VFMR groups, indicative of reduced MA contractility. The posterior mitral leaflet (PML) angle was smallest in the AFMR group and largest in the control group, whereas the distal anterior mitral leaflet angle did not significantly differ among the three groups.Conclusion HVR 3D-TEE improves the 3D temporal resolution greatly. LA remodeling causes expansion of the MA and reduced MA contractility, disruption of the annular saddle shape, and atriogenic PML tethering. Finally, atrial FMR occurs. Comparison of atrial FMR patients with and without LV dysfunction indicates that atriogenic PML tethering is an important factor that aggravates FMR.
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Bai et al. (2023) conducted an observational in Nonvalvular atrial fibrillation with functional mitral regurgitation (n=104). Atrial fibrillation with functional mitral regurgitation vs. Fever patients without heart disease was evaluated on Mitral valve geometric parameters including annulus area fraction and posterior mitral leaflet angle. In patients with atrial fibrillation, left atrial remodeling leads to mitral annulus expansion, reduced contractility, and atriogenic posterior mitral leaflet tethering, which aggravates functional mitral regurgitation.
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